Antibiotic pouch reduces implantable device infection rate

The pouch holds the device, and elutes the antibiotics minocycline and rifampin

Wrapping implantable cardiac implantable electronic devices (CIEDs) in an envelope that elutes antibiotics reduces the risk of major device infection, a clinical trial shows.

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Nearly 7000 patients at increased risk of device infection were enrolled in the WRAP-IT trial and randomly allocated to have their device implanted as normal, or inserted wrapped in a polymer-coated knitted-mesh envelope that eluted minocycline and rifampin.

The rate of infections resulting in extraction or revision of the device, long-term antibiotic therapy with recurrence or death

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