Australian study quantifies aspirin risk for GI bleeds

Data from the ASPREE trial suggests the risk of serious GI bleed rises with age and comorbidity

Elderly patients who take low-dose aspirin have a 60% increased relative risk of major gastrointestinal (GI) bleeding compared with peers not using the medication, an Australian study suggests.  

The large, randomised controlled trial also showed that the absolute risk of bleeding rose significantly with increasing age and certain risk factors, including chronic kidney disease (CKD).  

For a healthy 70-year-old with no identifiable risk factors who did not take aspirin, the researchers estimated their absolute five-year risk of a GI bleed was 0

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