Avoid off-label use of SGLT2-inhibitors for T1DM, warns TGA

Reports of diabetic ketoacidosis linked to the agents have prompted the regulator to remind doctors of the medicines’ indication

The TGA is urging prescribers to heed warnings against the use of SGLT2 inhibitors for patients with type 1 diabetes because of the increased risk of diabetic ketoacidosis.


In its latest Medicines Safety Update, the TGA reveals that last year it received six reports of SGLT2 inhibitors  being used for patients with type 1 diabetes despite the drugs not being approved for this indication.

Three of the reports were adverse events linked to diabetic ketoacidosis (DKA), the