Clozapine gets boxed warning on ‘potentially fatal’ GI effects

Screening for constipation is recommended as one in 10 fatal clozapine reports are related to gut disorders, says the TGA

GPs seeing patients on clozapine are being warned to monitor for signs and symptoms of gastrointestinal hypomotility following concern over serious adverse events, including fatalities.

Product information for the atypical antipsychotic has been updated and a boxed warning added because of post-market adverse events and emerging reports in the medical literature, the TGA says.