The TGA is investigating reports of toxicity in infants given compounded products for wind and colic that contained Atropa belladonna.

Last month, the watchdog warned doctors that anticholinergic toxidrome — with symptoms including erythematous skin, tachycardia, drowsiness and seizures — in young children exposed to these products could be caused by belladonna toxicity.

The TGA said it had received 23 adverse event reports related to a colic mixture containing belladonna, a toxic herbaceous plant in the nightshade family, including three cases each of mydriasis, lethargy and overdose.

While it did not evaluate compounded treatments for colic and wind treatments, the TGA said the pharmacists must compound preparations in line with Pharmacy Board of Australia guidelines.