Concomitant SSRIs and oral anticoagulants up major bleed risk: study
The likelihood of major bleeding peaks in the first 30 days of concomitant use, researchers say.
Concomitant use of SSRIs and oral anticoagulants increases the risk of major bleeding by a third in older adults with AF compared with use of oral anticoagulants alone, Canadian doctors report.
Their results, published in JAMA Network Open, suggest the likelihood of major bleeds peaks in the first 30 days of concomitant use and persists for up to six months.
In light of their findings, the McGill University-led team said major bleeding risk was “a pertinent safety consideration” for patients taking both drugs.
The population-based study included 42,000 primary care patients (mean age 74) with AF and major bleeding and 1.16 million matched controls with AF alone.
