The unexpected death of a 21-year-old from anaphylactic shock after surgery to remove his appendix has led a coroner to call for a TGA investigation into the anaesthetic reversal agent used.

Experiencing acute right abdominal pain, right shoulder pain, fever and vomiting, Lucas Peyret was originally referred to the Prince of Wales Hospital in Sydney by a GP in May 2019.

However, the law clerk experienced a “severe and unexpected” anaphylactic reaction to sugammadex, a modified gamma cyclodextrin used in the reversal of neuromuscular blockade.

A NSW coroner’s court was told that his heart stopped for 23 minutes, his brain was starved of oxygen and he never recovered, dying 10 days later.