Doctors say they have found the ‘missing link’ that explains severe food allergy caused by histamines in foods such as pizza, after treating a patient with three distinct symptom phases. 

The 36-year-old man presented with episodes of recurrent, dry flushing that occurred every 3-6 weeks involving his neck, chest and inner arms and thighs. 

It was preceded by gastrointestinal symptoms, including nausea, malaise, fatigue and a fever, lasting for two days, say the doctors from the family and internal medicine departments at Semmelweis University in Budapest, Hungary. 

He also had lack of appetite, occasional vomiting and a pulsating unilateral headache.