Fracture risk higher with warfarin than NOACs

Researchers urge caution over prescribing the anticoagulant in AF patients at high risk of fracture

Warfarin is associated with a raised risk of fracture compared with non-vitamin K antagonist oral anticoagulants (NOACs), a large real-world study has found.

Hip fracture

The US researchers evaluated the safety of warfarin versus NOACs in relation to fracture risk in more than 167,000 patients (mean age 69, and 62% men) with non-valvular AF who were prescribed one of the oral anticoagulants over a six-year period.

Overall, 49% were treated with warfarin and 51% with a NOAC — 11%