Only one elevated FSH result is necessary to diagnose premature ovarian insufficiency in the presence of disordered menstruation, according to updated international advice.

It says doctors no longer need to wait for multiple FSH levels >25 IU/L if women have had 4-6 months of disordered menses and are not pregnant or using hormonal treatments.

However, repeat FSH measurement or anti-müllerian hormone testing may be needed to confirm the diagnosis if the first set of FSH numbers is inconclusive.

The 2024 update to the 2015 Evidence-based guideline on premature ovarian insufficiency — published last December by a team of Australian, European and US clinical researchers — includes revised recommendations for diagnosis, genetic testing and treatment options.