Low-dose opioid–analgesic combo effective in osteoarthritis: review

Researchers say it’s debatable if single-ingredient opioids are appropriate for managing these patients

A combination of low-dose opioids and simple analgesics may be preferable for osteoarthritis compared with single-ingredient opioids, an Australian study finds. 


Not only is pain relief improved but patients are less likely to experience adverse events, researchers say after conducting a systematic review and meta-analysis of 36 randomised, placebo-controlled trials.

They found single-ingredient opioid medications, such as tramadol or oxycodone, could provide immediate, short- and medium-term relief for pain and disability in people with knee or hip