Low-dose opioid–analgesic combo effective in osteoarthritis: review

Researchers say it’s debatable if single-ingredient opioids are appropriate for managing these patients

A combination of low-dose opioids and simple analgesics may be preferable for osteoarthritis compared with single-ingredient opioids, an Australian study finds. 

Not only is pain relief improved but patients are less likely to experience adverse events, researchers say after conducting a systematic review and meta-analysis of 36 randomised, placebo-controlled trials.