Lowering serum urate levels no benefit in CKD: study

A trial shows prescription of allopurinol has no effect in slowing progression of the disease

A widely held belief that lowering elevated blood urate levels might put the brakes on the worsening of kidney disease has been rebutted by Australian-led research.

International studies suggest up to 20% of patients are being prescribed the gout medication allopurinol off-label to slow progression of kidney disease, says Associate Professor Sunil Badve, nephrologist and researcher from the George Institute for Global Health in Sydney.

But a randomised controlled trial he co-led found no significant slowing in the decline in eGFR in