Methotrexate shows promise for inflammatory hand OA in Aussie study

The drug could be effective for patients with an inflammatory phenotype, Dr Paul Kubler says.
Rachel Fieldhouse
Dr Paul Kubler.

Methotrexate is a safe and effective low-cost treatment for adults with symptomatic hand osteoarthritis and synovitis, Australian rheumatologists report in a landmark study.

Their trial is the first to show that the immunosuppressant provides a moderate but clinically meaningful benefit for reducing hand osteoarthritis (OA)-related pain and stiffness compared with placebo.