Oral vancomycin should be first-line for C. diff: new guidelines
In the first changes since 2016, ASID cited a trial suggesting metronidazole was inferior.

Oral vancomycin replaces metronidazole as first-line treatment for Clostridioides difficile in new guidelines from infectious diseases physicians.
In the first changes since 2016, the Australasian Society for Infectious Diseases (ASID) cited a head-to-head randomised controlled trial suggesting metronidazole was inferior to vancomycin for treatment of C. difficile infection (CDI).