Osteoporosis drug class 'worsens CKD'

The increased risk is moderate but clinicians should carefully consider initiation of the therapy in certain patients, researchers say

Bisphosphonate use in patients with moderate-to-severe CKD can worsen renal function and increase the risk of dialysis or transplant, a study has found.

Although contraindicated for those with an eGFR below 35mL/min, the findings should prompt careful consideration of the first-line osteoporosis drugs in patients with milder CKD, the UK and Spanish researchers say.

The team analysed data from two large primary-care patient datasets to determine whether CKD worsened faster among users of oral bisphosphonates compared with non-users.

Nearly 4000 new bisphosphonate users with CKD stage 3b-5,

Latest

Trending