Patient dies from bowel obstruction linked to clozapine

Warnings about the antipsychotic's gastrointestinal effects need greater prominence, coroner says

A coroner has called for a stronger warning on the risk of clozapine-induced gut hypomotility after a patient taking the drug died from complications of a bowel obstruction.

The inquest found that the 35-year-old patient, who was diagnosed with chronic paranoid schizophrenia at age 22, died as a result of acute vomit aspiration in the context of severe megacolon, back in April 2015.