PPIs not linked to pneumonia or dementia

Previous studies reporting an association were prone to biases and 'lack biological plausibility', say researchers

Proton-pump inhibitor (PPI) use is not linked with an increased risk of dementia, pneumonia or intestinal infections, and an association with chronic kidney disease (CKD) is likely due to residual confounding, research suggests.

While several studies have linked PPIs to adverse outcomes, much of this research is based on observational data, the Canadian authors say.

A randomised controlled trial recently found