Pregabalin overdose leading to coma and intubation: study

Toxicologists warn about growing recreational use and co-ingestion of sedatives

Comas and seizures are occurring among patients who overdose on pregabalin, Australian researchers say, after reviewing almost 500 hospitalisations.

Pregabalin

Their five-year study has found recreational use of pregabalin skyrocketed from 4% of overdoses in 2014 to almost 40% in 2019, backing the view that abuse has grown since its PBS-listing in 2013.

The neuropathic pain therapy is now the sixth-most prescribed drug on the PBS and is often prescribed to vulnerable patients, warn the toxicologists, from the University of Queensland and University of Newcastle.

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