Prenatal antiepileptics linked to later behaviour issues

Almost one-third of children exposed to valproate had a psychiatric diagnosis, study shows

Children exposed prenatally to their mothers' antiepileptic medication have an increased risk of behavioural problems compared with population norms, according to a study in the Netherlands.

antenatal

Researchers studied behavioural problems in children exposed to valproate, carbamazepine, lamotrigine or levetiracetam monotherapy as part of a larger longitudinal study of the long-term effects of prenatal exposure to antiepileptic drugs.

Mothers were on therapy before conception and continued during the entire pregnancy. Children were aged between six and eight during the

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