Is tramadol really safer than codeine for non-cancer pain?

Primary care study shows a new tramadol prescription is associated with a significantly higher risk of all-cause mortality than one for codeine
Reuters Health

Codeine may be a safer bet than tramadol for chronic non-cancer pain, according to a new study from Spain.

Tramadol is increasingly used to manage chronic non-cancer pain, but few safety studies have compared it with other opioids, say researchers from the Foundation University Institute for Primary Health Care Research, Barcelona, in JAMA.