Tricyclic antidepressant an effective second-line option for IBS: study
Amitriptyline could be considered in patients with moderate to severe IBS, say UK doctors.
Low-dose amitriptyline is a safe and effective second-line treatment for moderate to severe irritable bowel syndrome, according to UK doctors behind the first trial of its kind conducted entirely in primary care.
The University of Leeds–led team said the tricyclic antidepressant was superior to placebo for relieving irritable bowel syndrome (IBS) symptoms in adults who failed to respond to dietary changes, fibre supplements and other first-line therapies.
