Older women who take supplements with high doses of vitamins B6 and B12 may be more likely than those who don’t to experience hip fractures, a US study suggests.

While some previous research has linked both of these vitamins to a lower risk of heart disease, results have been mixed, with some studies also tying B6 and B12 to fractures in older adults, researchers note in JAMA Network Open.

For the current study, researchers followed almost 76,000 female nurses in the US for an average of 21 years, conducting extensive dietary surveys roughly every four years.

Almost all the women in the study had total intake of B6 and B12 from foods and supplements that was higher than recommended.