Warning over adverse PPI effect that can lead to seizure: case

A Canadian doctor has shared the case of a patient who developed severe electrolyte imbalance after being continuously prescribed the drugs

A Canadian doctor is reporting a case of severe electrolyte imbalance leading to grand mal epileptic seizure, to draw attention to an under-recognised complication with PPI therapy.

His 55-year-old patient first presented to an outpatient clinic in 2015 with a one-year history of intermittent chronic diarrhoea, up to eight times per day, resulting in a 12kg weight loss.

Her symptoms began shortly after her GP prescribed ranitidine 150mg daily for dyspepsia.