Warning over oral fluconazole in pregnancy

Doctors advised to consider topical antifungals after research links fluconazole to musculoskeletal malformations

Doctors have been urged to be cautious in prescribing oral fluconazole to women in their first trimester as it appears to raise the risk of congenital musculoskeletal malformations.

Even though the absolute risk was small, the researchers said topical anti-fungals should be considered in treating vulvovaginal candidiasis in early pregnancy.

“Oral fluconazole during the first trimester, especially prolonged treatment at higher than commonly used doses, should be prescribed with caution, and