Erectile dysfunction drugs sildenafil, tadalafil and vardenafil have significant beneficial effects in pulmonary arterial hypertension, an Australian Cochrane review confirms.

Melbourne researchers investigated the efficacy of phosphodiesterase 5 (PDE5) inhibitors for pulmonary hypertension in adults and children in their systematic review of 36 studies with 2999 participants with pulmonary hypertension from all causes.