When should you add in a non-statin therapy?

New global guidance recommends when to use ezetimibe and PCSK9 inhibitors in hard-to-treat patients at high risk of a CVD event

New guidance should help doctors better manage hard-to-treat hypercholesterolaemia in patients at very high-risk of a cardiovascular event, say its authors.

In their BMJ paper, published earlier this month, the international panel of clinicians recommends when to use ezetimibe and/or PCSK9 inhibitors in patients with high LDL cholesterol (LDL-C) who are on a the maximum dose of statins or are intolerant to them.

They say the new advice is needed because it is “almost impossible” to achieve LDL-C targets in patients