How a tiny worm is helping to find a cure for an extremely rare cancer
When the Williamson family from Dundee, UK lost their mother Sue to a rare cancer named phaeochromocytoma in 2003, they didn’t realise that further devastation was to follow.
Of her four children, twins Jennie and James discovered that they also have the faulty gene that cut short their mother’s life. Both twins are affected with inoperable tumours wrapped around vital blood vessels and nerves in their necks.
Father Jo decided to appear in a Cancer Research pledge video (below) in memory of his wife and to raise awareness of the important work that cancer researchers do for people like his children.
We have been working closely with the family to understand more about the gene mutation that causes this cancer. Along with a consortium of researchers from universities in Hungary and India, we have, for the first time, been able to recreate the Williamson defect in a tiny worm, just one millimetre long. This progress is vital to better understand the mutation, and it helps point to possible treatments for the cancer.