Space flights are all the rage, but what happens to immunity up there?

VSS Unity
VSS Unity, image courtesy of NASA.

The suppression of the immune system during space flight is a well-documented phenomenon.

During the Apollo missions in the ’60s and ’70s, for instance, many astronauts became sick with colds and other infections within a week of their return to Earth.

Clinicians have also observed the reawakening of dormant viral infections, such as herpes simplex, varicella zoster and Epstein-Barr viruses, among returned space travellers.

Despite being considered a major health risk, the mechanisms behind the immunosuppressive effects of microgravity in space have hitherto been nebulous.