Adding surgical closure 'superior to anti-TNF alone' for Crohn's fistula

The multidisciplinary approach has been demonstrated to improve outcomes over 18 months follow-up

Short-term anti-TNF treatment with surgical closure leads to higher rates of radiological healing in patients with Crohn’s perianal fistulas than anti-TNF therapy alone, research shows.

The PISA-II study, a first-of-its-kind direct comparison, also demonstrated improved quality of life and fewer reinterventions in those offered the combined approach to treatment, European clinicians say.

Given its superiority, they suggest that individuals with surgically amenable