Adding surgical closure ‘superior to anti-TNF alone’ for Crohn’s fistula

The multidisciplinary approach has been demonstrated to improve outcomes over 18 months follow-up

Short-term anti-TNF treatment with surgical closure leads to higher rates of radiological healing in patients with Crohn’s perianal fistulas than anti-TNF therapy alone, research shows.

The PISA-II study, a first-of-its-kind direct comparison, also demonstrated improved quality of life and fewer reinterventions in those offered the combined approach to treatment, European clinicians say.