Addition of alteplase linked to superior survival in acute ischaemic stroke
A large database study shows patients treated with endovascular thrombectomy who also receive alteplase have lower odds of death and disability
Endovascular thrombectomy combined with IV alteplase for acute ischaemic stroke leads to superior survival and functional outcomes compared to thrombectomy alone, a registry-based study shows.
US and Canadian researchers have reported that patients treated with the combination approach were nearly 20% less likely to die than those who missed out on the thrombolytic.
However, the addition of alteplase to endovascular thrombectomy (EVT) was associated with greater susceptibility to symptomatic intracranial haemorrhage.
In their multicentre observational study, the University of Calgary-led team analysed data from 15,800 older adults with acute ischaemic stroke who were treated with EVT within six hours of time last known well.
