Amlodipine 'has legacy effect' on stroke risk

Pitted against a beta-blocker, amlodipine offers superior stroke protection but no effect has been seen on dementia

Five years of blood-pressure lowering with amlodipine, compared with atenolol, reduces stroke risk for the next two decades in patients with cardiovascular risk factors, researchers have shown.

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But despite this benefit, their study failed to find that the early intervention reduced dementia risk.

The UK investigators used electronic health records to determine whether participants in the ASCOT trial, which recruited between 1998 and 2002, derived long-term