Wrapping implantable cardiac implantable electronic devices (CIEDs) in an envelope that elutes antibiotics reduces the risk of major device infection, a clinical trial shows.

Nearly 7000 patients at increased risk of device infection were enrolled in the WRAP-IT trial and randomly allocated to have their device implanted as normal, or inserted wrapped in a polymer-coated knitted-mesh envelope that eluted minocycline and rifampin.