Antibiotics cut ventilation pneumonia risk: study

A randomised controlled trial was undertaken in 16 ICUs

Two days of prophylactic antibiotic treatment administered shortly after cardiac arrest can cut early ventilation-associated pneumonia in selected patients, a French trial shows.

Person in ICU on ventilator

Nearly 200 adult patients, with out-of-hospital cardiac arrest with shockable rhythm and on targeted temperature management between 32°C and 34°C, were randomised either to injections of amoxicillin-clavulanate (1g/200mg three times daily) or to saline placebo injections for two days.

Targeted temperature management was a known