Better LATE than never: Name given to disease mimicking Alzheimer's

About half of people aged over 80 may have protein pathology related to the condition

A recently recognised dementia clinically resembles Alzheimer's disease but has different pathology, according to a consensus working group report.


The working group has proposed Limbic-predominant age-related TDP-43 encephalopathy (LATE) as the new terminology.

They suggest guidelines for the autopsy evaluation and staging of LATE neuropathological change, and review the medical literature pertaining to the condition in Brain.

The protein involved is called transactive response DNA binding protein of 43kDa (TDP-43).

It is often seen