Biologic safer than systemic corticosteroids for pemphigoid: study

Rituximab in combination with standard therapy leads to remission in three-quarters of patients, review shows.
Rachel Fieldhouse

The monoclonal antibody rituximab is just as effective as systemic corticosteroids in treating patients with pemphigoid, but is associated with fewer adverse events, according to a systematic review.

The drug was also the only biologic agent to result in partial or complete remission, with Chinese clinicians finding no benefit from treatment with dupilumab, omalizumab or mepolizumab.