Can biopsy be skipped in diagnosis of coeliac disease?

Almost all adults with very high titres of two antibodies have histology indicative of the disease, authors say

Diagnosis of coeliac disease without a biopsy is possible with high specificity in adults and children, although the sensitivity is low, a UK study suggests.

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Researchers looked at three cohorts: 740 patients treated at a specialist coeliac clinic in Sheffield, a further 532 referred for upper gastrointestinal endoscopy with a low suspicion for coeliac disease, and 145 patients with high with IgA antitissue transglutaminase (tTG) antibody from several sites.

Among the first cohort, the sensitivity and

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