Can you predict which patients will need a hip or knee replacement?

An Australian-developed genetic risk score could provide a 'personalised' approach to managing osteoarthritis

Using genetic risk scores to predict the likelihood a patient will need a hip or knee replacement could help prevent disease progression to severe osteoarthritis, Melbourne researchers say.

Their findings suggest that over-70s who score highly for a certain groups of genetic variants are at 44% and 88% increased risk of knee or hip replacement, respectively, than those with low scores.

The Monash University-led team says the scores could be incorporated into existing decision support tools for a more personalised