Cancer in men: BRCA2 mutations ‘more important’ than BRCA1
Results from international study might help guide screening, researchers say
Men with germline BRCA2 pathogenic variants are more at risk of cancer than those with BRCA1 mutations, a study shows.
International researchers examined data on more than 6900 men, of whom 3651 carried BRCA1 and 3251, BRCA2, pathogenic variants.
Participants (median age 52 years) were recruited by study groups worldwide from cancer genetic clinics between 1966 and 2017.
Nearly 20% had at least one cancer diagnosis, the researchers report in JAMA Oncology.
