Clozapine may be best second-generation antipsychotic for severe schizophrenia
There are adverse cardiometabolic effects, authors caution
8th August 2019
Clozapine appears to be more effective for severe schizophrenia than other second-generation antipsychotics, but safety concerns remain, a systematic review and meta-analysis suggest.
US researchers searched the literature for non-randomised cohort studies reporting effectiveness and/or safety outcomes when comparing clozapine with other second-generation antipsychotics (SGAs) in schizophrenia or schizoaffective disorder.
They included data from 63 cohort studies involving more than 109,000 patients in the meta-analysis, published in