Clozapine may be best second-generation antipsychotic for severe schizophrenia

There are adverse cardiometabolic effects, authors caution

Clozapine appears to be more effective for severe schizophrenia than other second-generation antipsychotics, but safety concerns remain, a systematic review and meta-analysis suggest.

Molecular structure of clozapine

US researchers searched the literature for non-randomised cohort studies reporting effectiveness and/or safety outcomes when comparing clozapine with other second-generation antipsychotics (SGAs) in schizophrenia or schizoaffective disorder.

They included data from 63 cohort studies involving more than 109,000 patients in the meta-analysis,