Combination treatment shows promise for psoriatic arthritis: study

Addition of leflunomide to methotrexate therapy may be valuable for patients with active disease, researchers say

Methotrexate plus leflunomide is a more effective treatment option for psoriatic arthritis than methotrexate monotherapy, but less well tolerated, a single-centre randomised trial shows.

Dutch researchers say their findings add to a growing body of evidence to support the “seemingly superior efficacy” of this combination therapy for patients with active disease.

“Clinicians might consider using this combination in either a step-down or -up approach depending on the situation,” said study author Dr Michelle