Concomitant SSRIs and NSAIDs 'raise risk of GI bleeds'

NSAIDs should be discontinued or a PPI added if the antidepressant is indicated, researcher suggests

Adding an SSRI significantly increases the odds of developing an upper gastrointestinal bleed in patients on NSAIDs, according to findings from a systematic review and meta-analysis.

Man holding two pills

Based on data from 10 studies, the US investigators found a 75% increase in the odds of gastrointestinal (GI) bleeding with concomitant use of the agents.

"It is known that NSAID use increases the risk for upper GI bleeding and previous studies have shown that SSRIs can also increase the likelihood of upper GI bleeding by