Concomitant SSRIs and NSAIDs ‘raise risk of GI bleeds’

NSAIDs should be discontinued or a PPI added if the antidepressant is indicated, researcher suggests
Reuters Health
Man holding two pills

Adding an SSRI significantly increases the odds of developing an upper gastrointestinal bleed in patients on NSAIDs, according to findings from a systematic review and meta-analysis.

Based on data from 10 studies, the US investigators found a 75% increase in the odds of gastrointestinal (GI) bleeding with concomitant use of the agents.