Concomitant SSRIs and NSAIDs ‘raise risk of GI bleeds’
NSAIDs should be discontinued or a PPI added if the antidepressant is indicated, researcher suggests
![Man holding two pills](https://www.ausdoc.com.au/wp-content/uploads/2022/08/comparing_two_pills_dreamstime_l_57698221-1.jpg)
Adding an SSRI significantly increases the odds of developing an upper gastrointestinal bleed in patients on NSAIDs, according to findings from a systematic review and meta-analysis.
Based on data from 10 studies, the US investigators found a 75% increase in the odds of gastrointestinal (GI) bleeding with concomitant use of the agents.