Could a cryoprotein explain 'COVID toe'?

Study at a Spanish hospital during the pandemic shows two thirds of patients with chilblains had an abnormal blood protein

Patients with ‘COVID toe’ may have an abnormal cryoprotein in their blood, a study suggests.


The research shows almost two thirds of 54 patients who presented at a hospital in northern Spain with chilblains at the height of the pandemic tested positive for cryofibrinogen.

The abnormal protein signals cryofibrinogenaemia — a rare disorder that can be primary or secondary to another disorder including infections, collagen diseases, vasculitis and malignancy.

The study was carried out at a tertiary