Could a cryoprotein explain ‘COVID toe’?

Study at a Spanish hospital during the pandemic shows two thirds of patients with chilblains had an abnormal blood protein
Clare Pain
COVID toe

Patients with ‘COVID toe’ may have an abnormal cryoprotein in their blood, a study suggests.

The research shows almost two thirds of 54 patients who presented at a hospital in northern Spain with chilblains at the height of the pandemic tested positive for cryofibrinogen.

The abnormal protein signals cryofibrinogenaemia — a rare disorder that can be primary or secondary to another disorder including infections, collagen diseases, vasculitis and malignancy.

The study was carried out at a tertiary hospital in Santander between April and May 2020.