Day-of-injury plasma concentrations of glial fibrillary acidic protein and ubiquitin C-terminal hydrolase L1 have good-to-excellent prognostic value for predicting death and unfavourable outcomes among patients with traumatic brain injury, according to a study published in the September issue of The Lancet Neurology.

Frederick K Korley, MD, PhD, from the University of Michigan in Ann Arbor, and colleagues enrolled patients from the Transforming Research and Clinical Knowledge in Traumatic Brain Injury observational cohort study to examine the prognostic accuracy of glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase L1 (UCH-L1) as day-of-injury predictors of functional outcome after traumatic brain injury (TBI).