Denosumab and alendronate provide similar fracture outcomes: study

Better bone mineral density may not necessarily translate into fewer fractures, authors say

Rates of osteoporotic fracture are similar three years after starting either denosumab or alendronate, according to a real-world Danish population-based cohort study.

X-ray fractured hip

Using national registries, the team investigated fracture risk in people aged 50 and older (mean age 71, 81% female) who were starting denosumab (4624 patients) or alendronate (87,731 patients).

The three-year cumulative incidence of hospitalisation for hip fracture was 3.7% in the denosumab cohort and 3.1% in the alendronate cohort — a difference that did not reach statistical significance.

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