Is diastolic BP a modifiable risk factor for hypertrophic cardiomyopathy?

The condition is often polygenic with many common gene variants contributing risk, researchers find

Diastolic blood pressure may be a key modifiable risk factor in patients with hypertrophic cardiomyopathy who don't carry one of the rare genetic mutations known to cause the condition, UK researchers say.

blood pressure machine

The genome-wide association study, reported in Nature Genetics, included 2780 cases of which 64% were sarcomere-negative and nearly 47,500 controls.

The team identified 12 genome-wide significant susceptibility loci for hypertrophic cardiomyopathy (HCM).

Single-nucleotide polymorphism heritability