Discontinuation of infliximab in IBD 'threatens relapse'

But the groundbreaking study finds histological remission is predictive of successful withdrawal

Long-term use of the anti-TNF agent infliximab might lead to an increased risk of malignancy or infection, according to Japanese researchers, but about one in four patients with ulcerative colitis (UC) will relapse if they quit using the biologic.

Ulcerative colitis seen on endoscopy

As the number of patients receiving maintenance treatment with infliximab is increasing, "questions have arisen regarding whether infliximab could be discontinued in some patients," the study team notes in the The Lancet